An Overview on Formulation and Evaluation Aspects of Tablets
DOI:
https://doi.org/10.22270/ajdhs.v2i4.23Keywords:
Tablets, Solid unit dosage, Compression method, Indian pharmacopoeia, Manufacturing, EvaluationsAbstract
Nothing in this world is stable and ever accepted. Change is the requirement of nature for the sake of adaptability. However, the pharmaceutical world is also not far off from this change. Technical advancement in pharma world also leads to the development of new dosages forms. This leads to the replacement of the older dosages forms with the newer once. But for the tablet dosages forms this replacement is substituted with modifications. On the top of it the availability of numerous evaluation parameters provides these new modifications in tablets a clear cut demonstration idea. Tablets are defined as solid unit dosage form of medicaments intended for oral use. They became most popular as they were easy in preparation compared to any other type of dosage forms. But the major drawback exists in its manufacturing. If any minor problem occurs during their manufacturing then the whole batch of the unit should be discarded. It is necessary to avoid any sort of errors during its manufacturing and as a result evaluation of tablets is very important before dispatching of a batch. In the present study, we discussed about the manufacturing techniques and evaluation tests for tablets.
Keywords: Tablets, Solid unit dosage, Compression method, Indian pharmacopoeia, Manufacturing, Evaluations
References
Arshad MS, Zafar S, Yousef B, Alyassin Y, Ali R, AlAsiri A, Chang MW, Ahmad Z, Elkordy AA, Faheem A, Pitt K. A review of emerging technologies enabling improved solid oral dosage form manufacturing and processing. Advanced drug delivery reviews. 2021; 178:113840. https://doi.org/10.1016/j.addr.2021.113840
Gaikwad SS, Kshirsagar SJ. Review on Tablet in Tablet techniques. Beni-Suef University Journal of Basic and Applied Sciences. 2020; 9(1):1-7. https://doi.org/10.1186/s43088-019-0027-7
Haritha B. A Review on Evaluation of Tablets. J Formul Sci Bioavailab 2017; 1: 107.
Gautam SP, Rai JP, Billshaiya U, Jain N, Vikram P, Jain DK. Formulation and evaluation of mouth dissolving tablet of loperamide. International Journal of Pharmaceutical Sciences and Research. 2013; 4(5):1782.
Patel AN, Rai JP, Jain DK, Banweer JI. Formulation, development and evaluation of cefaclor extended release matrix tablet. Int J Pharm Pharm Sci. 2012; 4(4):355-7.
Pandey SP, Khan MA, Dhote V, Dhote K, Jain DK. Formulation development of sustained release matrix tablet containing metformin hydrochloride and study of various factors affecting dissolution rate. Sch Acad J Pharm. 2019; 8(3):57-73.
Jain P, Nair S, Jain N, Jain DK, Jain S. Formulation and evaluation of solid dispersion of lomefloxacin hydrochloride. International Journal of Research in Pharmaceutical Sciences. 2012; 3 (4): 604-608.
Bi YX, Sinnada H, Yonezawa H. Evaluation of rapidly disintegrating tablets by direct compression method, Drug Dev Ind Pharma 1999; 25: 571-581. https://doi.org/10.1081/DDC-100102211
Ishikawa T, Koizumi N, Mukai B. Pharmacokinetics of acetaminophen from rapidly disintegrating compressed tablet prepared using microcrystalline cellulose (PH-M-06) and spherical sugar granules. Chem Pharm Bull 2001; 49: 230-32. https://doi.org/10.1248/cpb.49.230
Shangraw RF. Direct Compression Tableting, Encyclopedia of Pharmaceutical Technology, Vol-4, Marcel Dekker, USA, 2nd ed., 1988: 85-160.
Suhel T., Jain V., Khangar P.K., Jain R.K. Formulation and Evaluation of Metformin Hydrochloride Sustained Release Tablet. International Journal of Medical Sciences and Pharma Research, 2022; 8(3), 28-32. https://doi.org/10.22270/ijmspr.v8i3.56
Herbert L, Lachman L, Schwartz BJ. Chewable tablet Pharmaceutical dosage forms: Tablets. 1989; 2: 711-715.
Valenta C, Kast CE, Harich I, Bernkop-Schnurch A. Development and In Vitro Evaluation of a Mucoadhesive Vaginal Delivery System for Progesterone. J Cont Release 2001, 77: 323-332. https://doi.org/10.1016/S0168-3659(01)00520-X
Yong CS, Jung JH, Rhee JD, Kim CK, Choi HG. Physiological Characterization and Evaluation of Buccal Adhesive Tablets Containing Omeprazole. Drug Dev Ind Pharm 2001, 27: 447-445. https://doi.org/10.1081/DDC-100104320
Aburahma MH, El‐Laithy HM, Hamza YE. Preparation and in vitro/in vivo Characterization of porous sublingual tablets containing ternary kneaded solid system of Vinpocetine with β‐ Cyclodextrin and hydroxy acid. Sci Pharma 2010; 78: 363-379. https://doi.org/10.3797/scipharm.0912-04
Kathiresan K, Vijin P, Moorthi C, Manavalan R. Formulation and Evaluation of loratadine Chewable tablets. Res J Pharm Bio Chem Sci 2010; 2: 763-774.
Jagdale S, Gattani M, Bhavsar D, Kuchekar B, Chabukswar A. Formulation and Evaluation of Chewable Tablets of Levamisole. Int J Res Pharma Sci 2010; 1: 282-289.
Mullarney MP, Hancock BC, Carlson GT, Ladipo DD, Langdon BA. The powder flow and compact mechanical properties of sucrose and three high-intensity sweeteners used in chewable tablets. Int J Pharma 2003; 257: 227-236. https://doi.org/10.1016/S0378-5173(03)00144-3
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Copyright (c) 2022 Neeta Kushwaha, Anushree Jain, Prateek Kumar Jain, Basant Khare, Yashwant Singh Jat
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