A Comprehensive Review on Tailoring an Herbal Approach for Treatment of Poly Cystic Ovarian Syndrome

Authors

  • Arpana Purohit Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001
  • Sameeksha Jain Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001
  • Prakhar Nema Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001
  • Deepak Kumar Jain Sun Institute of Pharmaceutical Education & Research (SIPER), Bhatpura Road, Lahar, Bhind, MP, 477445
  • Harshna Vishwakarma Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001
  • Prateek Kumar Jain Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001

DOI:

https://doi.org/10.22270/ajdhs.v2i1.13

Keywords:

Poly cystic ovarian syndrome, Herbal medicine, Herbs, Natural plants

Abstract

The review gives a brief about poly cystic ovarian syndrome (PCOS) and the symptoms related to the disease. Around 2.2 to 26% of cases of PCOS are present globally. The disorder generally occurs in the reproductive age group of women. The review has a mention of few herbs which can be used to correct the diseased condition. The various herbs have a positive effect on the diseased condition and can be used to cure symptoms like hypothyroidism, hyperplasia, obesity, diabetes, Menorrhagia, sleep disturbances, cardiovascular problems, hyperlipidemia, hirsutism, infertility, irregular menstrual cycle, etc. The herbs included in the review include Bauhinia variegata useful in hormone imbalance, Phyllanthus emblica, Terminalia bellirica, Terminalia chebula, and Commiphora wightii are used to regulate the hormones, Cinnamon cassia acts as an anti-oxidant, Tribulus terrestris improves reproductive dysfunction, Hypericum perforatum regulates depression, Commiphora myrrha prevents menorrhagia, Nigella sativa controls cholesterol, Saraca asoca has estrogenic action, Asparagus racemosus promotes folliculogenesis, Tinospora cordifolia regulates menstrual flow, Ocimum sanctum as an anti-oxidant. The plants taken had a positive effect on women with PCOS without causing any side effects. The natural herbs used for the treatment of PCOS did not have any side effects and treated the diseased condition naturally. This review aims to understand the natural plants available for the treatment of the disease naturally. The herbs can be used individually or can be used in combination.

Keywords: Poly cystic ovarian syndrome, Herbal medicine, Herbs, Natural plants

Author Biographies

Arpana Purohit, Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001

Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001

Sameeksha Jain, Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001

Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001

Prakhar Nema, Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001

Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001

Deepak Kumar Jain, Sun Institute of Pharmaceutical Education & Research (SIPER), Bhatpura Road, Lahar, Bhind, MP, 477445

Sun Institute of Pharmaceutical Education & Research (SIPER), Bhatpura Road, Lahar, Bhind, MP, 477445

Harshna Vishwakarma, Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001

Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001

Prateek Kumar Jain, Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001

Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001

References

Eshre TR. Asrm-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril., 2004; 81(1):19-25. https://doi.org/10.1016/j.fertnstert.2003.10.004

Ozcan Dag Z, Alpua M, Isik Y, Buturak SV, Tulmac OB, Turkel Y. The evaluation of temperament and quality of life in patients with polycystic ovary syndrome. Gynecol Endocrinol., 2017; 33(3):250-3. https://doi.org/10.1080/09513590.2016.1254610

Celik O, Acbay O. Effects of metformin plus rosuvastatin on hyperandrogenism in polycystic ovary syndrome patients with hyperlipidemia and impaired glucose tolerance. J Endocrinol Investig., 2012; 35(10):905-10.

Norman RJ, Dewailly D, Legro RS, Hickey TE. Polycystic ovary syndrome. Lancet. 2007; 370(9588):685-97. https://doi.org/10.1016/S0140-6736(07)61345-2

Helvaci N, Yildiz BO. Oral contraceptives in polycystic ovary syndrome. Minerva Endocrinol., 2014; 39(3):175-87.

Seaman HE, de Vries CS, Farmer RD. Venous thromboembolism associated with cyproterone acetate in combination with ethinyloestradiol (Dianette): observational studies using the UK general practice research database. Pharmacoepidemiol Drug Saf., 2004; 13(7):42-36. https://doi.org/10.1002/pds.896

Messinis IE. Ovulation induction: a mini review. Hum Reprod., 2005; 20(10):2688-97. https://doi.org/10.1093/humrep/dei128

Tannus S, Burke YZ, Kol S. Treatment strategies for the infertile polycystic ovary syndrome patient. Womens Health (Lond)., 2015; 11(6):901-12. https://doi.org/10.2217/whe.15.40

Dayani Siriwardene SA, Karunathilaka LP, Kodituwakku ND, Karunarathne YA. Clinical efficacy of ayurveda treatment regimen on sub fertility with poly cystic ovarian syndrome (PCOS). Ayu. 2010; 31(1):24-27. https://doi.org/10.4103/0974-8520.68203

Patelanuradha J, Thakor AP. Prospective use of tephrosia purpureain remedial treatment of pcos: Study in wistar rat. Int Res J Biol Sci., 2012; 1(3):1-6.

Latha ST, Prasanna JL, Rani MJ, Divya K, Babu AMS. A review on natural remedies for prevailing polycystic ovarian disorder. Indo Am J Pharm., 2015; 5(10):3307-3315.

Franik S, Kremer JA, Nelen WL, Farquhar C. Aromatase inhibitors for subfertile women with polycystic ovary syndrome. Cochrane Database Syst Rev., 2014; 2:CD010287. https://doi.org/10.1002/14651858.CD010287.pub2

Balen AH, Morley LC, Misso M, Franks S, Legro RS, Wijeyaratne CN, et al. The management of anovulatory infertility in women with polycystic ovary syndrome: an analysis of the evidence to support the development of global WHO guidance. Hum Reprod Update., 2016; 22(6):687-708. https://doi.org/10.1093/humupd/dmw025

Abu HH. Twenty years of ovulation induction with metformin for PCOS; what is the best available evidence? Reprod BioMed Online., 2016; 32(1):44-53. https://doi.org/10.1016/j.rbmo.2015.09.015

Lunny CA, Fraser SN. The use of complementary and alternative medicines among a sample of Canadian menopausal-aged women. J Midwifery Womens Health., 2010; 55(4):335-43. https://doi.org/10.1016/j.jmwh.2009.10.015

Barnes PM, Bloom B, Nahin RL. Complementary and alternative medicine use among adults and children; United States. Natl Health Stat Report. 2007.

Mobeen H, Afzal N, Kashif M. Polycystic ovary syndrome may be an autoimmune disorder. Scientifica (Cairo). 2016; 4071735. https://doi.org/10.1155/2016/4071735

Balaji S, Amadi C, Prasad S, Bala Kasav J, Upadhyay V, Singh AK, Surapaneni KM, Joshi A. Urban rural comparisons of polycystic ovary syndrome burden among adolescent girls in a hospital setting in India. BioMed Res Int., 2015; 158951. https://doi.org/10.1155/2015/158951

Choudhary K, Singh R, Garg A, Verma N, Purohit A, Deora D. An updated overview of polycystic ovary syndrome. Int J Biol Sci., 2019; 7(3):1-13. https://doi.org/10.22159/ijms.2019.v7i3.34248

Nowak DA, Snyder DC, Brown AJ, Demark-Wahnefried W. The effect of flaxseed supplementation on hormonal levels associated with polycystic ovarian syndrome: A case study. Curr Top Nutraceutical Res., 2007; 5(4):177-181.

Belwal T, Devkota HP, Singh MK, Sharma R. Chapter 3.40 - St. John's Wort (Hypericumperforatum), nonvitamin and nonmineral. Nutritional Supplements; Academic Press, 2019, pp. 415-432. https://doi.org/10.1016/B978-0-12-812491-8.00056-4

Mitsi C, Efthimiou K. Infertility: Psychological-psychopathological consequences and cognitive-behavioural interventions. Psychiatriki., 2014; 25(4) :293-302.

O'Reilly E, Sevigny M, Sabarre KA, Phillips KP. Perspectives of complementary and alternative medicine (CAM) practitioners in the support and treatment of infertility. BMC Complement Altern Med., 2014; 14:394. https://doi.org/10.1186/1472-6882-14-394

Rayburn WF, Gonzalez CL, Christensen HD, Stewart JD. Effect of prenatally administered hypericum (St John's wort) on growth and physical maturation of mouse offspring. Am J Obstet Gynecol., 2001; 184(2):191-195. https://doi.org/10.1067/mob.2001.108339

Canning S, Waterman M, Orsi N, Ayres J, Simpson N, Dye L. The efficacy of hypericumperforatum (st john's wort) for the treatment of premenstrual syndrome: A randomized, doubleblind, placebo-controlled trial. CNS Drugs. 2010; 24(3):207-225. https://doi.org/10.2165/11530120-000000000-00000

Insulite health PCOS. Herbal remedies for PCOS. Available from: https://pcos.com/herbal-remedies/.

Sing DC, Dhyani S, Kaur GA. Critical review on Guggulu[CommiphoraWightii(arn.) bhand.] & its miraculous medicinal uses. Int J Ayurveda Pharma Res., 2015; 3(1):1-9.

Kavitha A, Narendra BA, Kumar SM, Kiran VS. Evaluation of effect of commiphora wightii in dehydroepiandrosterone (DHEA) induced polycystic ovary syndrome (PCOS) in rats. Pharma Tutor., 2016; 4(1):47-55.

Rani R, Mishra S. Phytochemistry of guggul (commiphorawightii): A review. Asian J Res Chem., 2013; 6(4): 415-426.

Evans WC, Evans D, Trease GE. A taxonomic approach to the study of medicinal plants and animal derived drugs. In: Trease and Evans pharmacognosy, 15th; WB Saunders: Edinburgh, New York, 2002.

Duke J, Duke PK, Cellier JL. Duke Handbook of medicinal herbs, 2nd; United States, 2002. https://doi.org/10.1201/9781420040463

Kostova I, Dinchev D. Saponins in tribulusterrestris-chemistry and bioactivity. Phytochem Rev., 2005; 4:111-137. https://doi.org/10.1007/s11101-005-2833-x

Abadjieva D, Kistanova E. Tribulus terrestris alters the expression of growth differentiation factor 9 and bone morphogenetic protein 15 in rabbit ovaries of mothers and f1 female offspring. PLoS One., 2016; 11(2):e0150400. https://doi.org/10.1371/journal.pone.0150400

Singh PP, Krishna A. Anti-hyperglycaemic activity of tribulusterrestrisfruit extract restores metabolic imbalance in letrozole induced -PCOS mice. Int J Pharmacogn Phytochem., 2019; 11(4):304-311.

Pachiappan S, Matheswaran S, Saravanan PP, Gayathiri M. Medicinal plants for polycystic ovary syndrome: A review of phytomedicine research. Int J Herb., 2017; 5(2):78-80.

Kalia V, Jadav AN, Bhuttani KK. In vivo effect of Asparagus racemosus on serum gonadotrophin levels in immature female wistar rats. 2nd world congress of Biotech; Devision of Herbal medicine: NBRI: Lucknow, 2003, p. 40.

Gaitondé BB, Jetmalani MH. Antioxytocic action of saponin isolated from Asparagus racemosus Willd (Shatavari) on uterine muscle. Arch Int Pharmacodyn Ther., 1969; 179(1):121-129.

Sharma K, Bhavnagar M. Asparagus racemosus (Shatavari): A versatile female tonic. Int J Phar., 2011; 2(3):855-863.

Ahmad A, Husain A, Mujeeb M, Khan SA, Najmi AK, et al., A review on therapeutic potential of Nigella sativa: A miracle herb. Asian Pac J Trop Biomed., 2013; 3(5):337-352. https://doi.org/10.1016/S2221-1691(13)60075-1

Sheeraz M. Rational approach towards the role of kalawnji (nigella sativa linn) in marz-e- akyas khusyatur rehm (polycystic ovarian syndrome)-a review. Indo Am J Pharm., 2018; 8(5):1089-1096.

Sangal A. Role of cinnamon as beneficial antidiabetic food adjunct: A Review Adv Appl Sci Res., 2011; 2(4):440-450.

Vangalapati M, Prakash S. A review on pharmacological activities and clinical effects of cinnamon species. Res J Pharm Biol Chem Sci., 2012; 3(1): 653-663.

Kort DH, Lobo RA. Preliminary evidence that cinnamon improves menstrual cyclicity in women with polycystic ovary syndrome: A randomized controlled trial. Am J Obstet Gynecol., 2014; 211(5):487.E1-487.E6. https://doi.org/10.1016/j.ajog.2014.05.009

Borzoei A, Rafraf M, Niromanesh S, Farzadi L, Narimani F, Doostan F. Effects of cinnamon supplementation on antioxidant status and serum lipids in women with polycystic ovary syndrome. J Tradit Complement Med., 2017; 8(1):128-133. https://doi.org/10.1016/j.jtcme.2017.04.008

Netmeds. Kanchanar Guggulu: This ayurvedic formulation treats hormonal imbalance. Available from: https://www.netmeds.- com/health-library/post/kanchanar-guggulu-this-ayurvedic-formulation-treats-hormonal-imbalance

Khandelwal R, Nathani S. An ayurvedic approach to PCOS: A leading cause of female infertility. Int J Ayurveda Res., 2016; 1(3):77-82.

Chouhan B, Ramesh K, Mita K, Ramamurthy A, Nathani S. Triphala: A comprehensive ayurvedic review. Int J Res Ayurveda Pharm., 2013; 4(4): 612-617. https://doi.org/10.7897/2277-4343.04433

Aruljothi R, Thiruthani M. Review of saraca asoca for uterine tonic in traditional siddha medicine. Int J Curr Res Chem Pharm Sci, 2019; 6(6):1-3.

Satapathy S, Das N, Bandyopadhyay D, Mahapatra SC, Sahu DS, Meda M. Effect of tulsi (ocimum sanctum linn.) supplementation on metabolic parameters and liver enzymes in young overweight and obese subjects. Indian J Clin Biochem., 2017; 32(3):357-363. https://doi.org/10.1007/s12291-016-0615-4

Pachiappan S, Matheswaran S, Saravanan PP, Gayathiri M. Medicinal plants for polycystic ovary syndrome: A review of phytomedicine research. Int J Herb., 2017; 5(2):78-80.

Khanage SG, Subhash TY, Bhaiyyasaheb IR. Herbal drugs for the treatment of polycystic ovary syndrome (PCOS) and its complications. Pharm Res., 2019; 2(1):5-13.

Healthy living. Saraca asoca bark. Available from: https://healthyliving.natureloc.com/wp-content/uploads/2016/08/Ashoka-Bark4.

https://cdn.shopify.com/s/files/1/0058/0252/4783/articles/st-johns-wort-hypericum-perforatum-primary-v2.jpg?v=1567803563

Fahad T, Ismath S. Phytochemical & therapeutic potentials of Murrmakki (Commiphor amyrrha). Indian J Appl Res., 2018; 8(9):102-104.

There's an EO for that. Treat PCOS naturally using essential oils. Available from: https://www.theresaneoforthat.com/treat-pcos-naturally-using-essential-oils.

Barthelmess EK, Naz RK. Polycystic ovary syndrome: Current status and future perspective. Front Biosci (Elite Ed.)., 2014; 6:104-119. https://doi.org/10.2741/E695

Ghani U, Batool A, Rafeeq H, Naeem M. Advancement and future directions towards herbal treatment for various diseases. Saudi J Med Pharm Sci., 2019; 5(11):931-941. https://doi.org/10.36348/sjmps.2019.v05i11.003

Published

15.03.2022

How to Cite

Purohit, A. ., Jain, S. ., Nema, P. ., Jain, D. K. ., Vishwakarma, H. ., & Jain, P. K. . (2022). A Comprehensive Review on Tailoring an Herbal Approach for Treatment of Poly Cystic Ovarian Syndrome. Asian Journal of Dental and Health Sciences, 2(1), 27–32. https://doi.org/10.22270/ajdhs.v2i1.13

Citations

Most read articles by the same author(s)

1 2 > >>