An Update on the Recent Emergence of Candida auris

Authors

  • Monika Jain Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001
  • Anushree Jain Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001
  • Basant Khare Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001
  • Deepak Kumar Jain Sun Institute of Pharmaceutical Education & Research (SIPER), Bhatpura Road, Lahar, Bhind, MP, 477445
  • Rubeena Khan Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001
  • Dolly Jain Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001

DOI:

https://doi.org/10.22270/ajdhs.v2i1.11

Keywords:

Fungal infection, Candida, C. auris, Candidemia, Bloodstream infection

Abstract

The incidence of invasive fungal infections (IFI) caused by unusual pathogens is on the rise, partly driven by the increased population of immunocompromised patients. The emerging multidrug-resistant yeast pathogen Candida auris (C. auris) has been a source of concern as an agent of healthcare-associated infections. C. auris is emerging multidrug-resistant yeast that causes serious invasive infections with high mortality. It was first discovered in 2009, and since then, individual cases or outbreaks have been reported from over 20 countries on five continents. Controlling C. auris is challenging for several reasons: (1) it is resistant to multiple classes of antifungals, (2) it can be misidentified as other yeasts by commonly available Identification methods, and (3) because of its ability to colonize patients perhaps indefinitely and persist in the healthcare environment, it can spread between patients in healthcare settings. The transmissibility and high levels of antifungal resistance that are characteristic of C. auris set it apart from most other Candida species. A robust response that involves the laboratory, clinicians, and public health agencies is needed to identify and treat infections and prevent transmission. This review highlights epidemiology, pathogenesis, microbiological characteristics, clinical presentation, diagnostic challenges and treatment options of C. auris infections. Infection prevention measures to prevent spread of C. auris and special measures during an outbreak situation have also been reviewed. Rapid emergence of hospital onset C. auris is worrisome. Early diagnosis of C. auris is essential for better outcomes and the implementation of infection prevention measures. Lack of widespread awareness, absence of general availability of diagnostic testing methods, and limited options for treatment of C. auris infections make it a difficult-to-treat pathogen. Further studies are needed for better understanding of this emerging pathogen.

Keywords: Fungal infection, Candida, C. auris, Candidemia, Bloodstream infection

Author Biographies

Monika Jain, Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001

Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001

Anushree Jain, Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001

Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001

Basant Khare, Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001

Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001

Deepak Kumar Jain, Sun Institute of Pharmaceutical Education & Research (SIPER), Bhatpura Road, Lahar, Bhind, MP, 477445

Sun Institute of Pharmaceutical Education & Research (SIPER), Bhatpura Road, Lahar, Bhind, MP, 477445

Rubeena Khan, Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001

Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001

Dolly Jain, Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001

Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001

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Published

15.03.2022

How to Cite

Jain, M. ., Jain, A. ., Khare, B. ., Jain, D. K. ., Khan, R. ., & Jain, D. . (2022). An Update on the Recent Emergence of Candida auris. Asian Journal of Dental and Health Sciences, 2(1), 14–19. https://doi.org/10.22270/ajdhs.v2i1.11

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