Asian Journal of Dental and Health Sciences

Apicoectomy for Periapical Lesion Treatment after Post Endodontic Failure on First Maxillary Premolar (Case Study)

2023-02-09T15:51:26+00:00

Introduction. Factors that cause failure of endodontic therapy include incomplete cleaning and shaping of root canals and unhermetic obturation. Endodontic failure can lead to periapical lesions. Apicoectomy is one of endodontic surgery treatment choice to preserving the tooth with endodontic treatment failure. Aim. The aim of this report was to show that in cases of failure of root canal treatment could be treat without extraction, however there was an alternative treatments such as apicoectomy that could be used to preserve the tooth and its function in the oral cavity.Case. A male 32 years old patient came to dentist with persistent pain on upper left first premolar. The tooth had been endodontically treated for ten years. Clinical examination tooth #24 had porcelain fused to metal on it, percussion test (+), bite test (+), pain on palpation. Radiographic examination showed that tooth #24 had fabricated post without gutta percha obturation on apical third. There was 3 mm round periapical lesion on the distal side of the tooth. Procedure Apicoectomy and retrograde filling with Mineral Trioxide Aggregate (MTA) and bone graft was performed to eliminate that periapical lesion. Conclusion Apicoectomy is one of main choice to preserve post endodontic tooth with periapical lesion and post core crown on it, as long as possible in oral cavity

Keywords : Apicoectomy, Periapical lesion, Post endodontic treatment failure

Evaluation of Antioxidant Activity of Rosa indica Linn

2022-12-10T11:24:34+00:00

Plants have served human beings as a natural source for treatments and therapies from ancient times, amongst them medicinal herbs have gain attention because of its wide use and less side effects. In the recent years plant research has increased throughout the world and a huge amount of evidences have been collected to show immense potential of medicinal plants used in various traditional systems. Rosa indica symbol of godness and beauty known for various healing power, has astringent, sedative, anti-inflammatory and antidepressant qualities. The aim of the present study was to evaluate in vitro antioxidant activities of leaves of Rosa indica. The in vitro antioxidant activity of methanolic extract of the leave part was assessed against DPPH free radical scavenging assay methods using standard protocols. The activities of methanolic leave part extract against DPPH assay method were concentration dependent with IC 50 values of ascorbic acid and extracts 24.34 and 62.66μg/ml respectively. The diverse array of phytochemicals present in the plant thus suggests its therapeutic potentials which may be explored in drug manufacturing industry as well as in traditional medicine.

Keywords: Antioxidant activity, Rosa indica, DPPH assay method, Methanolic extract

Evaluation of In-Vitro Anti-Inflammatory Activity of Leaves of Pongamia pinnata

2022-12-10T11:25:56+00:00

Inflammation is a reaction of a living vascularised tissue to an injury. Conventional or synthetic drugs used in the treatment of inflammatory diseases are inadequate, it sometimes have serious side effects. So, number of herbal medicines is recommended for the treatment of inflammation that has no side effects. Pongamia pinnata, Pierre (Family- Fabaceae) commonly known as karanja. The seed and seed oil of the plant have been reported to be effective in various inflammatory and infectious diseases such as leucoderma, leprosy, lumbago, muscular and articular rheumatism, cutaneous affection including herpes and scabies etc. in folk medicine and Ayurveda, a traditional system of healing . Anti-inflammatory activities of this plant for various parts have been reported in various models. This study examined the anti-inflammatory potential of a methanolic leaves extract of Pongamia pinnata and reference drug Declofenac sodium, invitro using heat-induced protein denaturation technique. The concentrations of the leave extract used were 50-250μg/ml. While diclofenac sodium were 50, 100, 150, 200 and 250μg/ml. Both the Diclofenac sodium and extract showed the IC₅₀ values 18.36 and 82.24µg/ml respectively. It is concluded that the methanolic leaves extract of Pongamia pinnata possess marked in vitro anti-inflammatory activity which is mediated possibly by flavonoids, tannins and alkaloids. This is a novel finding. Further the results scientifically justify the use of leaves of Pongamia pinnata in India traditional medicine to treat inflammation.

Keywords: Inflammation, Pongamia pinnata, Fabaceae, heat-induced protein denaturation technique

Evaluation of Antioxidant Activity of Trigonella foenum graecum Seeds Extract

2022-12-03T11:13:47+00:00

In the current work, we completed a comprehensive assessment of the relative antioxidant activity in extracts from a few different medicinal plant species.The extracts' effectiveness at scavenging 1, 1-diphenyl-2-picryl hydrazyl (DPPH) radicals was assessed spectrophotometrically. The highest degree of radical scavenging was 52.54%, while the IC₅₀ value was 93.54.Trigonella foenum graecum extract demonstrates how the greater concentration of phytoconstituents chemicals leads to more powerful radical scavenging results.

Keywords: Trigonella foenum graecum, Antioxidant, DPPH, Phytochemical analysis