Evaluation of Biochemical Parameters of Patients with Type 2 Diabetes Mellitus Based on Age and Gender in Umuahia
DOI:
https://doi.org/10.22270/ajdhs.v3i2.43Keywords:
Type 2 diabetes mellitus, lipid profile, kidney function, liver function, glycated haemoglobin, fasting blood sugarAbstract
Diabetes mellitus is a major public health issue. The study was done to determine the changes in some biochemical parameters between type 2 diabetes mellitus patients and apparently healthy adults in Umuahia. The fasting blood glucose was significantly higher in females than in males in the diabetic population. The table revealed a significantly (P<0.05) higher levels of serum total cholesterol, trialytglycerol, LDL-cholesterol, in females than males, except low HDL cholesterol (P<0.05) compared to male matched patients. Glycated haemoglobin was significantly (P<0.05) higher in female than male. Creatinine was significantly (P<0.05) higher in male. Urea was also significantly (P<0.05) higher in female. Potassium was significantly (P<0.05) higher in females. Bicarbonate was significantly (P<0.05) lower in female.The study showed a significantly (P<0.05) higher levels of total cholesterol, trialyglycerol, LDL- cholesterol in patient’s aged between 57-74years, except low HDL-cholesterol (P<0.05) compared to those aged between 40-56years. Fasting blood glucose and HbAIC were significantly (P<0.05) higher in age limit 57-74years than 40-56years. Urea and creatinine were significantly (P<0.05) low in patients aged 57-74years when compared to age 40-56years. However, HDL concentration was significantly (P<0.05) high in the 40-56years when compared to 57-74years.Elevated levels of triglyceride (TG), total cholesterol (TC), and glycated haemoglobin (Glyc.Hb) and reduced levels of HD.
Keywords: Type 2 diabetes mellitus, lipid profile, kidney function, liver function, glycated haemoglobin, fasting blood sugar.
References
Okafor CJ, Yusuf SA, Mahmoud SA, Salum SS, Vargas SC, Mathew AE, Obeagu EI, Shaib HK, Iddi HA, Moh'd MS, Abdulrahman WS. Effect of Gender and Risk Factors in Complications of Type 2 Diabetic Mellitus among Patients Attending Diabetic Clinic in Mnazi Mmoja Hospital, Zanzibar. Journal of Pharmaceutical Research International. 2021; 33(29B):67-78. https://doi.org/10.9734/jpri/2021/v33i29B31591
Obeagu EI, Obeagu GU. Utilization of Antioxidants in the Management of Diabetes Mellitus Patients. J Diabetes Clin Prac. 2018; 1(102):2.
Obeagu EI, Okoroiwu IL, Obeagu GU. Some haematological variables in insulin dependent diabetes mellitus patients in Imo state Nigeria. Int. J. Curr. Res. Chem. Pharm. Sci. 2016; 3(4):110-7.
Albert K, Zimmet PZ. For the WHO consultation. Definition, diagnosis and classification of diabetes mellitus and its complications. Diabetic Medicine. 2003; 15:539-553. https://doi.org/10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
Trinder P. Determination of glucose in blood using oxidase with an alternative oxygen acceptor. Annual Clinical Biochemistry. 1999; 6:24-27. https://doi.org/10.1177/000456326900600108
International Diabetes Federation (2007). Diabetes atlas: IDF Brussels in diabetes mellitus.
World health Organization. The global burden: Diabetes and impaired glucose tolerance.2007.
Singh R, Fisch G, Teague B. Prevalence of impaired glucose tolerance among children and adolescents with marked obesity. New England Journal of Medicine. 2003; 346:802810. https://doi.org/10.1056/NEJMoa012578
Nwafor A, Owhoji A. Prevalence of diabetes mellitus among Nigerian in Port Harcourt, Journal of Applied science and Environmental Management. 2001; 5 (1):75-77. https://doi.org/10.4314/jasem.v5i1.54950
Winter WE. Type 2 diabetes mellitus. In Burtis, C. A. & Ashwood, E. R. (Eds). Tietz textbook of clinical chemistry and molecular diagnostic, 5th ed. (pp. 570-577). Philadelphia: W.B. Saunders. 2010.
Caroline D, Clifford JB. Obesity in the pathogenesis of type 2 diabetes. 2011.
Michael JF. Microvascular and Macrovascular complications of diabetes. Clinical Diabetes. 2008; 26(2):77-82. https://doi.org/10.2337/diaclin.26.2.77
Schonfield RG, Lowellen CS. Clinical Chemistry. 1968; 10:533
Norris KA, Atkinsoon AR, Smith WG. Clinical Chemistry. 1975; 21:1093- 1101. https://doi.org/10.1093/clinchem/21.8.1093
Bowers LD, Wong ET. A critical evaluation and review Clinical Chemistry. 1980; 26:555. https://doi.org/10.1093/clinchem/26.5.555
Wheatherburn MW. Analytical chemistry. 1967; 39:971. https://doi.org/10.1021/ac60252a045
Arntz HR. Diagnostic Hyperlipoproteinaemia. 1979; 3:177
Warran JH, Martin BC, Krowlewski AS, Soeldner JS, Kahn C. Slow glucose removal rate and hyperinsulinaemia precede the development of type 2 diabetes in the offspring of diabetic parents. Annals of Internal Medicine. 2010; 113:909-915. https://doi.org/10.7326/0003-4819-113-12-909
Stevenson JC, Crook JA. Influence of age and menopause on serum lipids and lipoproteins in healthy women. 2013.
Wokoma FS. Diabetes and hypertension in Africa- an overview, Diabetes international. 2002; 12(2):36-37.
Published
How to Cite
Issue
Section
Citations
Copyright (c) 2023 Godfrey Ogochukwu Ezema, Ndukaku Yusuf Omeh, Simeon Egbachukwu, Ejiofor C. Agbo, Adachukwu Pauline Ikeyi, Emmanuel Ifeanyi Obeagu

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.